Tokyo, Jan. 5 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060252) titled 'A Meta-analysis of the Incidence of Hypertension in Patients with Breast Cancer Treated with Anthracycline-based Chemotherapy' on Jan. 5.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Yokohama City University Graduate School of Medicine

Condition: Condition - Breast cancer patient Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - This study aims to enhance survivorship in cancer patients. We will perform a meta-analysis of randomized controlled trials to evaluate the incidence of hypertension in breast cancer patients treated with anthracyclines. Basic objectives2 - Safety

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Female Key inclusion criteria - We will include only English full-articles. The other article including non-English article, short article, and conference abstract will be excluded. We will include parallel-group individual randomized controlled trials (RCTs) but not cluster RCTs, or cross-over RCTs. A trial with three or more arms will be accepted. Along with superiority trials, non-inferiority trials will be allowed. Any phase RCT may be included. Trials not reporting data about safety outcomes will be excluded. Key inclusion criteria are as follows. 1) Randomized controlled trials involving adult patients with breast cancer receiving anthracycline-based therapy. 2) Multi-arm trials in which at least one treatment arm includes anthracycline-based therapy. 3) Trials reporting outcomes related to the incidence of hypertension. Key exclusion criteria - 1) Non-RCT. 2) The republished research literature is excluded unless the research includes new findings related to adverse events listed in inclusion criteria. 3) Studies with no or insufficient safety results at the time of the literature search. 4) Studies published in languages other than English. Two investigators independently screened all titles, abstracts, and full texts for eligibility. Final inclusion will be decided after resolving discrepancies between the two investigators.

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 07 Month 19 Day Anticipated trial start date - 2026 Year 01 Month 05 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068403

Disclaimer: Curated by HT Syndication.