Tokyo, April 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060996) titled 'A Multicenter Retrospective Study of Endoscopic Resection for Superficial Cancer at the Hypopharyngeal Esophageal Transition Zone' on April 1.

Study Type: Observational

Primary Sponsor: Institute - Kyoto University

Condition: Condition - Hypopharyngeal cancer, Esophageal cancer Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - Superficial cervical esophageal cancer and superficial hypopharyngeal cancer extending into the hypopharyngeal esophageal transition zone are relatively rare, and sufficient data regarding treatment outcomes and complications of endoscopic resection have not yet been accumulated. The aim of this study is to clarify treatment outcomes and complications by collecting clinical data from patients who underwent endoscopic resection for these diseases across multiple institutions. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1. Patients diagnosed with superficial cancer of the cervical esophagus or the hypopharynx extending into hypopharynegal esophageal transition zone who underwent endoscopic resection. 2. Histopathologically diagnosed squamous cell carcinoma, including high-grade intraepithelial neoplasia and severe dysplasia. 3. Negative deep resection margin in the resected specimen. 4. No clinical evidence of lymph node metastasis. 5. Availability of intraoperative endoscopic images. 6. Availability of formalin-fixed, paraffin-embedded (FFPE) tissue sections of the tumor obtained at the time of endoscopic resection. Key exclusion criteria - 1. Presence of unresectable multiple primary cancers in the head and neck or esophageal region at the time of endoscopic resection. 2. Presence of unresectable synchronous primary cancer in other organs at the time of endoscopic resection. 3. Cases with extremely short follow-up periods or an excessive amount of missing data, making reliable analysis difficult. Target Size - 100

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2025 Year 08 Month 05 Day Date of IRB - 1985 Year 08 Month 01 Day Anticipated trial start date - 2025 Year 08 Month 08 Day Last follow-up date - 2030 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068782

Disclaimer: Curated by HT Syndication.