Tokyo, Aug. 27 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062704) titled 'The significance of lipid change analysis in scoliosis surgery' on Aug. 26.

Study Type: Observational

Primary Sponsor: Institute - The University of Tokyo

Condition: Condition - Scoliosis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to investigate the perioperative dynamics of lipid mediators in posterior spinal fusion for scoliosis, a procedure associated with significant surgical invasiveness and severe postoperative pain. Posterior spinal fusion involves placing pedicle screws into the vertebrae and connecting them with rods to correct spinal curvature. Because of its invasiveness, postoperative pain management is often challenging. By examining temporal changes in lipid mediators during the perioperative period, we seek to identify novel therapeutic targets for inflammation and postoperative pain. Such approaches may reduce complications through improved inflammation control, facilitate earlier mobilization and discharge by alleviating postoperative pain, and ultimately contribute to better patient outcomes. Basic objectives2 - Others

Eligibility: Age-lower limit - 10 years-old = Gender - Male and Female Key inclusion criteria - Patients diagnosed with scoliosis and scheduled to undergo posterior spinal fusion under general anesthesia at the University of Tokyo Hospital

Patients aged 10 years or older and 20 years or younger

Patients who understand the purpose of this study and provide informed consent Key exclusion criteria - Patients for whom surgical cooperation cannot be obtained

Patients taking NSAIDs or tramadol preoperatively

Patients using prostaglandin preparations or lipid mediator antagonists (e.g., montelukast) preoperatively

Patients undergoing reoperation

Patients requiring chronic respiratory support due to scoliosis curvature Target Size - 15

Recruitment Status: Recruitment status - No longer recruiting Date of protocol fixation - 2025 Year 12 Month 04 Day Date of IRB - 2025 Year 10 Month 04 Day Anticipated trial start date - 2025 Year 12 Month 08 Day Last follow-up date - 2030 Year 03 Month 01 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067731

Disclaimer: Curated by HT Syndication.