Tokyo, May 19 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061616) titled 'Prospective study evaluating changes in vascular function after obesity treatment in patients with obesity and hypertension' on May 18.
Study Type:
Observational
Primary Sponsor:
Institute - Kagawa University Hospital
Condition:
Condition - Obesity complicated by hypertension
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - To prospectively evaluate the effects of pharmacological treatment with GLP-1 receptor agonists or GLP-1/GIP receptor agonists on flow-mediated dilation (FMD) in patients with obesity complicated by hypertension. In addition, exploratory analyses will be performed to investigate associations with autonomic nervous function (CVRR) and neuroendocrine markers (ACTH and serum cortisol).
Basic objectives2 - Others
Eligibility:
Age-lower limit - 18
years-old
<=
Age-upper limit - Not applicable
Gender - Male and Female
Key inclusion criteria - 1. Patients diagnosed with obesity who are scheduled to initiate treatment with GLP-1 receptor agonists or GLP-1/GIP receptor agonists
2. Patients complicated by hypertension (receiving antihypertensive medication or having outpatient blood pressure of 140/90 mmHg or higher)
3. Patients aged 18 years or older
4. Written informed consent for participation in this study
Key exclusion criteria - 1. Pregnant or breastfeeding women
2. Patients considered inappropriate for participation by the investigators
Target Size - 30
Recruitment Status:
Recruitment status - Enrolling by invitation
Date of protocol fixation - 2026 Year 01 Month 22 Day
Date of IRB - 2026 Year 02 Month 27 Day
Anticipated trial start date - 2026 Year 03 Month 01 Day
Last follow-up date - 2029 Year 12 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070494
Disclaimer: Curated by HT Syndication.
