Tokyo, Feb. 28 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060777) titled 'KMU Cranberry On Nocturnal Enuresis for Continence Trial' on Feb. 27.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Double blind -all involved are blinded Control - Placebo

Primary Sponsor: Institute - Kansai Medical University

Condition: Condition - Nocturnal enuresis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To evaluate the changes in the urinary microbiome following continuous consumption of cranberry extract supplement in children with nocturnal enuresis. Basic objectives2 - Others

Intervention: Interventions/Control_1 - Participants will receive cranberry extract supplement (5 tablets) once daily for 3 weeks. Interventions/Control_2 - Participants will receive placebo (5 tablets) once daily for 3 weeks.

Eligibility: Age-lower limit - 5 years-old = Gender - Male and Female Key inclusion criteria - 1) Children aged 5 to 15 years at the time of consent. 2) Outpatients. 3) Gender: Both male and female. 4) Diagnosed with nocturnal enuresis. 5) Patients from whom written informed consent has been obtained from the participant or their legal guardian after sufficient explanation and understanding. Key exclusion criteria - Children who meet any of the following criteria: 1) Use of antibiotics within the last month. 2) Routine consumption of cranberries or cranberry products. 3) Presence of underlying renal or urinary tract diseases. 4) Refusal to participate in this study. 5) Otherwise judged unsuitable for the study by the principal investigator. Target Size - 50

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2026 Year 02 Month 16 Day Date of IRB - 2026 Year 02 Month 16 Day Anticipated trial start date - 2026 Year 02 Month 27 Day Last follow-up date - 2029 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068873

Disclaimer: Curated by HT Syndication.