Tokyo, March 29 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061093) titled 'A study of surgical treatment as conversion therapy for initially unresectable biliary tract carcinoma' on March 28.

Study Type: Observational

Primary Sponsor: Institute - Tokyo Medical University

Condition: Condition - biliary tract carcinoma Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - Although biliary tract carcinoma is one of the malignancies with a very poor prognosis, recent advances in chemotherapy and radiotherapy have enabled conversion surgery to be performed in some patients with initially unresectable disease. However, the number of cases undergoing conversion surgery remains limited at individual institutions, and the factors enabling conversion surgery as well as the relationship between the duration of preoperative treatment and prognosis have yet to be fully elucidated. To date, no nationwide study addressing these issues in patients with initially unresectable biliary tract cancer has been conducted in Japan. The aim of this study is to conduct a nationwide analysis of cases from institutions accredited by the Japanese Society of Biliary Surgery and to clarify the clinical utility of conversion surgery, as well as the optimal timing for conversion, in patients with initially unresectable biliary tract carcinoma in Japan. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1,Patients aged over 20 years with initially unresectable biliary tract carcinoma who underwent preoperative treatment and subsequently became eligible for surgical resection 2,Patients with available preoperative clinicophysiological data and resected clinicopathological findings Key exclusion criteria - 1,Patients who did not have initially unresectable biliary tract carcinoma 2,Patients who declined to participate in the study Target Size - 270

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2026 Year 01 Month 21 Day Date of IRB - 2026 Year 01 Month 21 Day Anticipated trial start date - 2026 Year 01 Month 30 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069908

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