Tokyo, March 26 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061057) titled 'Anesthesia-related Risk Determinants of Post-Induction Hypotension in Emergency Surgery for Lower Gastrointestinal Perforation (GUARD-PIH study): A Multicenter Retrospective Observational Study' on March 25.
Study Type:
Observational
Primary Sponsor:
Institute - University of Toyama
Condition:
Condition - lower gastrointestinal perforation
Classification by malignancy - Malignancy
Genomic information - NO
Objective:
Narrative objectives1 - To assess the effects of anesthetic induction agents on the incidence of post-induction hypotension and peri-induction blood pressure changes, and to generate evidence to inform the optimal choice of induction agents in critically ill patients.
Basic objectives2 - Safety
Eligibility:
Age-lower limit - 20
years-old
<=
Age-upper limit - Not applicable
Gender - Male and Female
Key inclusion criteria - Patients who underwent emergency surgery for lower gastrointestinal perforation (ascending colon to rectum) between April 1, 2022, and October 31, 2025.
Key exclusion criteria - 1) Pregnancy, 2) Refusal of data use via the opt-out process, 3) Use of mechanical circulatory support, 4) Patients already intubated upon operating room admission, 5) Presence of a permanent tracheostomy or tracheostomy, 6) Missing key variables, including anesthetic induction agents or blood pressure measurements at induction, 7) Postoperative diagnosis indicating that the perforation site was outside the lower gastrointestinal tract
Target Size - 720
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 03 Month 06 Day
Date of IRB - 2026 Year 03 Month 18 Day
Anticipated trial start date - 2026 Year 04 Month 01 Day
Last follow-up date - 2029 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069637
Disclaimer: Curated by HT Syndication.
