Clinical Trial: Assessment of Pericoronary Adipose Tissue Attenuation and Its Diagnostic Utility in Coronary Microvascular Dysfunction (Japan)

Tokyo, Dec. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058675) titled 'Assessment of Pericoronary Adipose Tissue Attenuation and Its Diagnostic Utility in Coronary Microvascular Dysfunction' on Dec. 1.

Study Type: Observational

Primary Sponsor: Institute - Kobe University Hospital

Condition: Condition - coronary microvascular dysfunction Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To assess the association between CT value attenuation of pericoronary adipose tissue assessed using coronary CT and coronary microcirculatory impairment. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 18 years-old 50%) on coronary angiography (ii) Patients who have undergone invasive coronary function assessment (CFR and IMR) using a pressure wire (iii) Patients who have undergone coronary computed tomography angiography within 120 days before or after coronary angiography (iv) Patients aged 20 years or over who are eligible for consent Key exclusion criteria - (i) Patients with >=50% stenosis or occlusive lesion in any of the three branches or side branches with a vessel diameter of >=1.5 mm or fractional flow reserve (FFR) <=0.8 at coronary angiography (ii) Patients with a history of acute coronary syndrome (iii) Patients who have undergone revascularisation (percutaneous coronary intervention, coronary artery bypass grafting) in the past (iv) Patients with suspected hypertrophic cardiomyopathy, cardiac amyloidosis, or Fabry's disease (v) Patients with moderate or severe valvular disease (vi) Patients undergoing coronary perfusion assessment after cardiac surgery or percutaneous coronary intervention (vii) Patients with inadequate quality of coronary computed tomography angiography images and inability to assess PCAT attenuation (viii) Patients who refused to participate in the study Target Size - 150

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 08 Month 01 Day Anticipated trial start date - 2025 Year 08 Month 01 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066944

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