Tokyo, Sept. 30 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000063104) titled 'Association of Perioperative Serum Uric Acid Dynamics with Postoperative Delirium and Postoperative Cognitive Dysfunction: A Prospective Cohort Study in Intensive Care Unit Patients' on Sept. 29.

Study Type: Observational

Primary Sponsor: Institute - Kagawa University

Condition: Condition - Postoperative delirium; postoperative cognitive dysfunction Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The objective of this study is to investigate the association of perioperative serum uric acid levels and their changes with postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in older patients undergoing major surgery. Exploratory analyses will also examine the associations of gut-related factors with serum uric acid levels, POD, and POCD. Basic objectives2 - Others

Eligibility: Age-lower limit - 65 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1) Patients aged 65 years or older at the time of informed consent. 2) Patients scheduled for admission to the intensive care unit (ICU) after major surgery. 3) Patients considered able to undergo the assessments required for the primary and secondary outcomes according to the study protocol. 4) Patients who provide written informed consent to participate in the study. Key exclusion criteria - 1) Patients from whom informed consent for study participation cannot be obtained. 2) Patients scheduled to undergo intracranial surgery. 3) Patients with severe neurological disease, psychiatric disease, or dementia, or those considered unable to undergo assessment for postoperative delirium (POD) or postoperative cognitive dysfunction (POCD) because of aphasia, severe hearing impairment, severe visual impairment, prolonged disturbance of consciousness, or similar conditions. 4) Patients with alcohol dependence or a high risk of alcohol withdrawal. 5) Patients considered unsuitable for participation by the principal investigator or study investigators. Target Size - 350

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 05 Month 20 Day Date of IRB - 2026 Year 07 Month 31 Day Anticipated trial start date - 2026 Year 09 Month 30 Day Last follow-up date - 2029 Year 06 Month 29 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072209

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