Tokyo, Aug. 16 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062548) titled 'Circulating Interleukin-6 Levels Across Behcet's Disease and Large Vessel Vasculitis: A Systematic Review and Meta-analysis' on Aug. 10.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Yokohama City University Graduate School of Medicine

Condition: Condition - Behcet's Disease Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Behcet's disease (BD) is an inflammatory disease that can involve severe organ manifestations affecting the eyes, nervous system, blood vessels, and gastrointestinal tract, potentially leading to irreversible organ damage. Circulating interleukin-6 (IL-6) levels have been reported to be associated with disease activity and severe organ involvement in BD. IL-6 is also known to play an important role in the pathogenesis of large vessel vasculitis. This study aims to conduct a systematic review and meta-analysis of studies comparing circulating IL-6 levels between patients with BD, Takayasu arteritis, or giant cell arteritis and healthy controls, and to quantitatively evaluate the elevation of circulating IL-6 levels in each disease. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1 Studies including patients with Behcet's disease (BD), Takayasu arteritis, or giant cell arteritis 2. Studies including a healthy control group 3. Studies evaluating circulating IL-6 levels in both patients and healthy controls 4. Studies providing sufficient data on circulating IL-6 levels for meta-analysis Key exclusion criteria - 1. Case reports and case series including five or fewer patients 2. Duplicate publications based on the same or overlapping study population 3. Studies published in languages other than English 4. Conference abstracts or presentations not published as full-text original articles

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 08 Month 10 Day Anticipated trial start date - 2026 Year 08 Month 10 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071598

Disclaimer: Curated by HT Syndication.