Tokyo, March 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060760) titled 'Study on Salivary Secretion During Induction of General Anesthesia and Its Impact on Dental Anesthesia and Oral Surgery Conditions' on March 1.

Study Type: Observational

Primary Sponsor: Institute - Nagasaki university

Condition: Condition - Patients undergoing oral and maxillofacial surgery under general anesthesia Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The aim of this study is to quantitatively evaluate changes in salivary secretion during induction of general anesthesia and to clarify their impact on airway management by dental anesthesiologists and operative conditions in oral surgery. The primary outcome is salivary flow rate during tracheal intubation (SFR2). Associations with operator subjective assessment (VAS), patient characteristics, anesthesia-related factors, and salivary properties such as surface tension will be examined in a prospective observational study. The findings are expected to contribute to safer airway management and improved surgical conditions during induction of general anesthesia. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients who meet all of the following criteria will be included: 1. Patients scheduled for oral and maxillofacial surgery under general anesthesia 2. Age over 20 years 3. Written informed consent obtained after adequate explanation of the study Key exclusion criteria - Patients meeting any of the following criteria will be excluded: 1. History of salivary gland surgery 2. History of radiation therapy to the head and neck region 3. Regular use of medications known to cause xerostomia 4. Persistent subjective symptoms of oral dryness 5. Severe hepatic or renal dysfunction 6. Patients deemed inappropriate for participation by the investigator Target Size - 93

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 02 Month 26 Day Anticipated trial start date - 2026 Year 03 Month 01 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069525

Disclaimer: Curated by HT Syndication.