Tokyo, June 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060539) titled 'Clinicopathological Analysis of Renal Fibrosis-Related Molecules Using Human Kidney Biopsy Specimens' on June 1.

Study Type: Observational

Primary Sponsor: Institute - Saitama Medical University

Condition: Condition - Chronic Kidney Disease (CKD) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The objective of this study is to investigate the molecular pathological association between renal interstitial fibrosis, renal function indices (e.g., eGFR), and the expression of fibrosis-related molecules using archived human kidney biopsy specimens. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old =18 years old) with chronic kidney disease, regardless of sex, who are judged by the principal or co-investigators to fulfill all of the following criteria: Diagnosed with a major renal disease such as diabetic kidney disease, nephrosclerosis, or IgA nephropathy. Kidney biopsy specimens have been appropriately fixed and preserved, allowing for immunohistochemical assessment. Clinical laboratory data are documented in the electronic medical records. Key exclusion criteria - Cases where immunohistochemical evaluation is not feasible due to insufficient biopsy specimen quantity or inadequate preservation. Cases with significant gaps in follow-up data that prevent assessment of renal function progression. Cases with an unconfirmed or unclassifiable histopathological diagnosis (cases potentially requiring future re-evaluation of kidney biopsy findings are excluded from this study). Target Size - 500

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 01 Month 31 Day Anticipated trial start date - 2026 Year 06 Month 01 Day Last follow-up date - 2030 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069251

Disclaimer: Curated by HT Syndication.