Tokyo, Feb. 12 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060649) titled 'Equivalent Efficacy of Slow Eccentric vs. Concentric Training for Knee Osteoarthritis: A Myofascial Chain Approach in Middle-Aged Women' on Feb. 11.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -but assessor(s) are blinded Control - Active

Primary Sponsor: Institute - Qufu Normal University

Condition: Condition - Middle-aged and elderly female patients with moderate to severe knee osteoarthritis symptoms and basic mobility. Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to examine the comparative efficacy of slow eccentric-only training (SET) and slow concentric-only training (SCT) in improving clinical symptoms in middle-aged and older women with knee osteoarthritis (KOA), grounded in the theoretical framework of myofascial chains. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Slow Eccentric Training (SET) Group: Participants will perform resistance training focused on eccentric muscle contractions along the myofascial chains (superficial front, back, and lateral lines). Training will be supervised and conducted three times per week for 12 weeks. Each session includes 6 exercises, targeting key muscle groups involved in knee joint stability (e.g., quadriceps, hamstrings, gluteals, gastrocnemius), performed at 60 to 70% of 1 to RM, with 3 sets of 8 to 10 repetitions per exercise. The eccentric phase of each repetition will be executed at a slow tempo of 8 to 10 seconds, while concentric movement is minimized or assisted. Training intensity is adjusted biweekly based on reassessed 1 to RM. All sessions will be led by certified physical therapists. Interventions/Control_2 - Slow Concentric Training (SCT) Group: Participants will perform resistance training focused on concentric muscle contractions along the myofascial chains (superficial front, back, and lateral lines). Training will be conducted three times per week for 12 weeks under professional supervision. Each session includes 6 exercises targeting major lower limb muscle groups (e.g., quadriceps, hamstrings, gluteals, gastrocnemius), performed at 60 to 70% of 1 to RM, with 3 sets of 8 to 10 repetitions per exercise. The concentric phase of each repetition will be performed at a slow tempo of 8 to 10 seconds, while the eccentric phase is minimized or assisted. Training loads are adjusted biweekly according to reassessed 1 to RM values. All sessions are supervised by certified physical therapists to ensure safety and protocol adherence.

Eligibility: Age-lower limit - 50 years-old = Gender - Female Key inclusion criteria - Female participants aged between 50 and 70 years. Clinically diagnosed with knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria. Radiographic evidence of tibiofemoral osteophytes on X ray imaging. Experiencing knee joint pain on most days within the past month. Numeric Rating Scale (NRS) score for knee pain >= 4 in the past week. Able to understand study instructions and provide written informed consent. Physically able to participate in supervised resistance training. Key exclusion criteria - History of knee replacement surgery or scheduled for knee surgery during the study period. Diagnosed with rheumatoid arthritis, gout, or other forms of inflammatory joint disease. Severe cardiovascular, respiratory, neurological, or musculoskeletal disorders that may affect exercise tolerance. Current use of corticosteroid injections or intra-articular hyaluronic acid within the past 3 months. Body Mass Index (BMI) >= 35 Engaged in structured resistance training in the past 6 months. Cognitive impairment, mental illness, or inability to follow instructions. Participation in another clinical trial concurrently. Target Size - 56

Recruitment Status: Recruitment status - No longer recruiting Date of protocol fixation - 2024 Year 04 Month 05 Day Date of IRB - 2024 Year 04 Month 05 Day Anticipated trial start date - 2024 Year 04 Month 05 Day Last follow-up date - 2024 Year 04 Month 05 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069364

Disclaimer: Curated by HT Syndication.