Tokyo, March 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060795) titled 'Comparison between peripheral perfusion index and nailfold microcirculation: a single-center prospective observational study' on March 10.

Study Type: Observational

Primary Sponsor: Institute - Nagasaki University Hospital

Condition: Condition - Healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Peripheral Perfusion Index (PPI) derived from pulse oximetry quantifies peripheral circulation noninvasively and conveniently based on the pulse waveform amplitude and has been increasingly used in clinical research. Microcirculation is an important factor related to prognosis, but continuous assessment in routine practice is difficult because dedicated devices are required. Nailfold Video Capillaroscopy (NVC) can quantify nailfold microcirculation, yet it is not widely used in general clinical practice. If PPI correlates with NVC metrics, PPI may serve not only as a peripheral perfusion indicator but also as a surrogate marker of microcirculation. Primary objective is to evaluate the association between pulse oximetry-derived PPI (PAI and PI) and nailfold microcirculation metrics assessed by NVC (capillary blood flow velocity and capillary diameter). Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1. Healthy adults (staff of Department of Anesthesiology, operating room nurses, and clinical engineers at Nagasaki University Hospital). 2. Able to provide written informed consent. Key exclusion criteria - 1. Nail polish or other decorations on fingers. 2. Current smoker. 3. Underlying disease under active treatment. 4. People without cuticles Target Size - 30

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 01 Month 30 Day Anticipated trial start date - 2026 Year 03 Month 01 Day Last follow-up date - 2026 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069015

Disclaimer: Curated by HT Syndication.