Tokyo, May 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061402) titled 'Comprehensive analysis of the effects of chlorhexidine-containing mouthwash on oral bacteria' on May 1.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Open -no one is blinded Control - Placebo

Primary Sponsor: Institute - Hiroshima university

Condition: Condition - Oral disease Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to investigate the effects of mouthwash use on number of oral bacteria and the oral microbiota. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - After saliva collection and dental check up, participants gargle with chlorhexidine-containing mouthwash three times a day (morning, noon, and night) for about one to two weeks. They receive the saliva collection and dental checkup again. Interventions/Control_2 - After saliva collection and dental check up, participants gargle with fluoride mouthwash three times a day (morning, noon, and night) for about one to two weeks. They receive the saliva collection and dental checkup again.

Eligibility: Age-lower limit - 20 years-old = Gender - Male and Female Key inclusion criteria - 1. Individuals aged 20 to 49 at the time of obtaining consent. 2. Individuals in good health who are not at risk of accidental ingestion or aspiration when using mouthwash. 3. Individuals who can provide written consent to participate in this study. Key exclusion criteria - 1. Individuals who have been taking medications or supplements for a long period or on a continuous basis up to the time of obtaining consent. 2. Individuals at risk of hypersensitivity to mouthwash. 3. Others deemed unsuitable by the investigator. Target Size - 50

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2026 Year 04 Month 15 Day Date of IRB - 2026 Year 04 Month 20 Day Anticipated trial start date - 2026 Year 04 Month 20 Day Last follow-up date - 2029 Year 05 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070205

Disclaimer: Curated by HT Syndication.