Tokyo, June 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062034) titled 'Study of the Association Between Clonal Hematopoiesis (CHIP) and Coronary Plaque Characteristics' on June 24.

Study Type: Observational

Primary Sponsor: Institute - Kobe University Hospital

Condition: Condition - Atherosclerotic Coronary Artery Disease Classification by malignancy - Others Genomic information - YES

Objective: Narrative objectives1 - The aim of this study is to evaluate the impact of clonal hematopoiesis of indeterminate potential (CHIP) on coronary plaque phenotype using comprehensive coronary CT analysis. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients who underwent coronary computed tomography (CT) and subsequently underwent coronary angiography within 6 months of the CT scan.

Patients who participate in the study led by the National Cerebral and Cardiovascular Center on the clinical significance of somatic mosaicism, and for whom genetic analyses including CHIP are performed using blood samples collected at the time of coronary angiography.

Patients aged 18 years or older at the time of obtaining informed consent.

Patients who are able to understand the study procedures and provide written informed consent. Key exclusion criteria - Patients with a history of hematologic malignancy.

Patients with a history of bone marrow transplantation.

Patients who have received radiotherapy, chemotherapy, or immunotherapy for solid tumors within the past two years (patients treated with local surgery alone are not excluded).

Patients deemed inappropriate for inclusion in the study at the discretion of the principal investigator. Target Size - 600

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 04 Month 01 Day Anticipated trial start date - 2026 Year 06 Month 24 Day Last follow-up date - 2031 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070984

Disclaimer: Curated by HT Syndication.