Tokyo, Dec. 26 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060084) titled 'Development and Application of Treatment Optimization Technology Based on Depression Diagnosis and Stratification Markers' on Dec. 26.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Keio University

Condition: Condition - Mental disorders and healthy control Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Purpose of this study: The study will target participants in an existing dataset, the "Longitudinal MRI study to elucidate the neural circuit substrates associated with remission and recovery in mood disorders (commonly known as the L/R study)." The study will apply the "Depression Diagnostic and Stratification Brain Circuit Marker Program" to the acquired brain images. The aim is to evaluate the diagnostic brain circuit markers of participants in the L/R study and classify them into multiple depression subtypes, thereby clarifying the differences in treatment effects between standard treatments (pharmacotherapy, CBT, ECT, and rTMS) for each subtype. The data obtained during this verification process will also be used as training data to improve the accuracy of the program. Significance of this study: In clinical practice, there are no indicators that enable objective diagnosis, or methods that allow for the prediction and direct comparison of treatment effects and remission for various highly needed treatments. Some of the results obtained in this study regarding the "Depression Diagnostic Brain Circuit Marker Program" and the "Depression Stratification Brain Circuit Marker Program" may be used in future approval applications. It is believed that by using the "Depression Diagnostic Brain Circuit Marker Program" to distinguish depressed cases from healthy cases using MRI images, it will be possible to diagnose depression based on objective evidence. Similarly, by classifying depressed cases into multiple subtypes using MRI images and clarifying the differences in treatment effects when each subtype receives the four main treatments, it is believed that it will be possible to select individualized treatments for depression. This research will have a major impact on the clinical practice of depression, and the above is its significance. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 20 years-old = Gender - Male and Female Key inclusion criteria - Participants aged 20 years or older (both depressed and healthy) from the existing dataset, "Longitudinal MRI study to elucidate neural circuit mechanisms associated with remission and recovery in mood disorders (commonly known as the L/R study)." Key exclusion criteria - This study is an analytical study using an existing dataset, and will exclude 1. cases with insufficient medical information 2. cases who have expressed their intention not to participate through the opt-out process described below

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2024 Year 11 Month 18 Day Date of IRB - 2024 Year 11 Month 18 Day Anticipated trial start date - 2024 Year 11 Month 18 Day Last follow-up date - 2030 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068696

Disclaimer: Curated by HT Syndication.