Tokyo, Aug. 26 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058884) titled 'Diagnostic Performance of FFR-CT for Detecting Functional Ischemia in Patients with Moderate Stenosis on Coronary CT Performed for the Evaluation of Stable Angina: A Systematic Review and Meta-Analysis' on Aug. 26.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Yokohama City University

Condition: Condition - Coronary artery disease Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Coronary computed tomography (CT) is widely used for the evaluation of stable angina, and accurate assessment of the functional significance of moderate stenosis is essential. However, morphological assessment alone often fails to reliably determine the presence of ischemia. Recently, fractional flow reserve derived from CT (FFR-CT) has emerged as a promising noninvasive technique for functional assessment, but its diagnostic performance remains incompletely established. The objective of this study was to systematically evaluate the diagnostic performance of FFR-CT for detecting functional ischemia in patients with moderate stenosis on coronary CT performed for the evaluation of stable angina. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Studies were eligible if they evaluated the diagnostic performance of CT-FFR using invasive FFR < 0.80 as the reference standard in patients undergoing coronary CT for the evaluation of stable angina, including those with moderate stenosis. Eligible outcomes included the diagnostic accuracy of CT-FFR in all patients, in patients with moderate stenosis, and stratified by different software. Only original research articles with clearly defined study populations and sufficient quantitative data (e.g., sensitivity, specificity, or AUC) compared against invasive FFR were included. Key exclusion criteria - Reviews, case reports, conference abstracts, and non-human studies were excluded. Studies that did not use FFR < 0.80 as the reference standard, did not provide sufficient quantitative data on CT-FFR diagnostic performance, or were duplicate publications were also excluded. Articles not published in English were excluded as well.

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2024 Year 09 Month 17 Day Date of IRB - 2024 Year 09 Month 17 Day Anticipated trial start date - 2024 Year 09 Month 17 Day Last follow-up date - 2025 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067344

Disclaimer: Curated by HT Syndication.