Tokyo, Jan. 6 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060258) titled 'Effect of exercise modalities on blood myokine concentrations' on Jan. 5.
Study Type:
Interventional
Study Design:
Basic Design - Cross-over
Randomization - Randomized
Blinding - Open -no one is blinded
Control - No treatment
Primary Sponsor:
Institute - Hyogo Medical University
Condition:
Condition - healthy adults
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - Myokines suppress cognitive decline and several types of cancer, but its secretion requires high-intensity exercise that is often unfeasible for frail patients. This study aims to investigate whether low-intensity neuromuscular electrical stimulation (NMES) can increase circulating myokine levels by inducing localized anaerobic metabolic stress, thereby serving as a "metabolic bypass" that avoids excessive systemic cardiovascular strain.
Basic objectives2 - Efficacy
Intervention:
Interventions/Control_1 - NMES group: 30-min of lower-body NMES applied via belt electrodes at a frequency of 4 Hz. Intensity is set to the highest tolerable level, with a heart rate ceiling of 120% of VT1.
Interventions/Control_2 - Control group: 30-min of passive rest in the supine position.
Eligibility:
Age-lower limit - 20
years-old
<=
Age-upper limit - Not applicable
Gender - Male
Key inclusion criteria - Healthy adult men aged 20 years or older
Key exclusion criteria - Presence of orthopedic or neuromuscular disorders, or having implanted electronic devices
Target Size - 12
Recruitment Status:
Recruitment status - Completed
Date of protocol fixation - 2018 Year 03 Month 22 Day
Date of IRB - 2018 Year 03 Month 22 Day
Anticipated trial start date - 2018 Year 03 Month 22 Day
Last follow-up date - 2025 Year 12 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068928
Disclaimer: Curated by HT Syndication.
