Tokyo, Dec. 16 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060088) titled 'Effect of focused extracorporeal shock waves on walking-induced hypoxia in knee osteoarthritis with bone marrow lesions' on Dec. 15.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Non-randomized Blinding - Open -no one is blinded Control - Active

Primary Sponsor: Institute - Morinomiya University of Medical Sciences

Condition: Condition - Knee osteoarthritis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To determine whether focused extracorporeal shock waves improve walking-induced hypoxia in patients with knee osteoarthritis and bone marrow lesions Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - foucusd extracorporeal shock wave therapy: 0.27 mJ/mm2, 2000 shots, 4 Hz, administered once weekly for 3 weeks to the site with bone marrow lesions. Physical therapy: Once weekly. Interventions/Control_2 - Physical therapy: Once weekly.

Eligibility: Age-lower limit - 40 years-old = Gender - Male and Female Key inclusion criteria - Patients diagnosed with osteoarthritis of the knee, with a Visual Analogue Scale evaluation of 30 mm or more at the medial knee joint and bone marrow lesions at the medial tibiofemoral joint on MRI. Key exclusion criteria - Grade IV in the Kellgren-Lawrence classification, history of knee trauma or neurological disease, bilateral symptomatic knee osteoarthritis, bone marrow lesions with osteonecrosis on MRI findings, systemic diseases such as rheumatoid arthritis, autoimmune diseases, tumors, and contraindications to ESWT systemic diseases such as rheumatoid arthritis, autoimmune diseases, and tumors, as well as those with contraindications to extracorporeal shock wave therapy. Target Size - 32

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 15 Day Anticipated trial start date - 2025 Year 12 Month 15 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068723

Disclaimer: Curated by HT Syndication.