Tokyo, July 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061876) titled 'Effect of Visual Information on Salivary Responses to Taste Stimulation' on July 1.
Study Type:
Interventional
Study Design:
Basic Design - Cross-over
Randomization - Randomized
Blinding - Open -no one is blinded
Control - No treatment
Primary Sponsor:
Institute - Institute of Science Tokyo
Condition:
Condition - Not applicable; exploratory study in healthy adults
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - To examine the effects of differences in visual information during taste stimulation on salivary secretion, salivary alpha-amylase activity, and subjective evaluations in healthy adults.
Basic objectives2 - Others
Intervention:
Interventions/Control_1 - Umami stimulation group: Participants receive 10 mL of 0.3% monosodium glutamate solution. Transparent and brown-colored conditions are presented in randomized order, and salivary secretion volume, salivary alpha-amylase activity, salivary pH, and subjective evaluations are assessed.
Interventions/Control_2 - Sour stimulation group: Participants receive 10 mL of a 0.1% citric acid solution. Transparent and yellow-colored conditions are presented in randomized order. Salivary secretion volume, salivary alpha-amylase activity, salivary pH, and subjective evaluations are assessed.
Eligibility:
Age-lower limit - 18
years-old
=
Gender - Male and Female
Key inclusion criteria - 1. Individuals aged 18 years or older and younger than 65 years at the time of consent
2. Individuals who understand the study procedures and provide written informed consent
3. Individuals whose physical condition is stable on the day of the study
Key exclusion criteria - 1. Individuals with food allergies, including allergies to MSG, citric acid, or food colorants
2. Individuals who are pregnant or breastfeeding
3. Individuals with acute oral conditions, such as severe stomatitis or acute toothache
4. Individuals with self-reported severe oral dryness or severe underlying diseases that may affect salivary secretion
5. Individuals who smoke on the day of the study
6. Individuals with a history of severe discomfort or allergic symptoms caused by taste stimulation, including MSG or citric acid
7. Individuals judged by the principal investigator or study investigators to be unsuitable for participation
Target Size - 90
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 06 Month 11 Day
Anticipated trial start date - 2026 Year 07 Month 15 Day
Last follow-up date - 2028 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070795
Disclaimer: Curated by HT Syndication.
