Tokyo, Sept. 19 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059126) titled 'Effectiveness of High-Flow Nasal Cannula Oxygen Therapy in Adult Patients with Chest Trauma: A Systematic Review and Network Meta-analysis' on Sept. 18.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Japan Self Defense Forces Sapporo Hospital

Condition: Condition - chest trauma Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Although noninvasive positive pressure ventilation (NIV) has been shown to reduce intubation rates and complications compared to conventional oxygen therapy (COT) in patients with chest trauma, its use can be limited due to discomfort during application or contraindications such as facial injuries. High-flow nasal cannula (HFNC) therapy has attracted attention as an alternative that offers better tolerability and continuous oxygen delivery. In recent years, reports on the utility of HFNC have increased, but the conclusions remain inconsistent. This study aims to systematically review and evaluate the clinical effectiveness of HFNC therapy compared to COT and NIV in patients with chest trauma, with a particular focus on its potential to avoid endotracheal intubation. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Adult patients with chest trauma requiring oxygen therapy will be included. A comprehensive literature search will be conducted to capture a broad range of relevant studies. The characteristics of the retrieved studies will then be examined to confirm the clinical and methodological coherence of the patient populations, and only eligible studies will be included in the network meta-analysis. Studies that do not meet the inclusion criteria but are considered relevant will not be incorporated into the network and will instead be reported narratively. Key exclusion criteria - No exclusion criteria will be predefined. After the analysis, variability in exclusion criteria across the included studies will be described.

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 09 Month 18 Day Date of IRB - 2025 Year 09 Month 18 Day Anticipated trial start date - 2025 Year 09 Month 18 Day Last follow-up date - 2026 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066637

Disclaimer: Curated by HT Syndication.