Tokyo, Dec. 8 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059948) titled 'Effectiveness of Whole Blood Transfusion in Adult Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis' on Dec. 8.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - National Defense Medical College

Condition: Condition - traumatic brain injury Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Balanced transfusion, in which plasma, platelets, and red blood cells are administered in fixed ratios, have been widely adopted as a standard approach for patients with severe trauma. In contrast, whole blood transfusion containing platelets has recently been evaluated as emerging evidence suggests a potential survival benefit in patients with traumatic hemorrhagic shock, particularly in the United States. However, most of these findings are derived from studies focusing on polytrauma, and the effectiveness of whole blood transfusion in patients with traumatic brain injury remains unclear. This study aims to systematically identify and synthesize the existing literature on whole blood transfusion in patients with traumatic brain injury, and to evaluate its clinical effectiveness and safety through a systematic review and meta-analysis. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 16 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients aged 16 years or older with traumatic brain injury will be included. A comprehensive literature search will be conducted to capture a wide range of relevant studies. The characteristics of the retrieved studies will then be examined to ensure clinical and methodological consistency across patient populations, after which eligible studies will be selected for inclusion in the meta-analysis. Studies that do not meet the eligibility criteria but are considered relevant will be summarized narratively. Key exclusion criteria - 1. Studies not involving human subjects 2. Pediatric cases (patients younger than 16 years) 3. Subgroup analyses in which no traumatic brain injury cases are included 4. Single-arm studies, case reports, conference abstracts, or protocol-only publications 5. Articles not written in English

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 12 Month 02 Day Date of IRB - 2025 Year 12 Month 02 Day Anticipated trial start date - 2025 Year 12 Month 02 Day Last follow-up date - 2026 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068569

Disclaimer: Curated by HT Syndication.