Tokyo, Oct. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062869) titled 'Effects of Anesthetic Maintenance Agents on Hemodynamic Changes Following Pneumoperitoneum' on Oct. 1.

Study Type: Observational

Primary Sponsor: Institute - The university of tokyo.

Condition: Condition - laparoscopic surgery Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Since its introduction into clinical practice, remimazolam has become widely used as an anesthetic agent associated with minimal circulatory depression. However, intraoperative hypertension occurs more frequently with remimazolam than with propofol; a randomized controlled trial involving gynecological laparoscopic surgery demonstrated that mean arterial pressure was significantly higher in the remimazolam group after the patient was returned to a horizontal position. Differences in the anesthetic agents' effects on the autonomic nervous system are suggested to underlie these variations in circulatory response. Nevertheless, most existing studies compare remimazolam with propofol, with limited data comparing it to inhalational anesthetics. Furthermore, no studies have directly compared the temporal changes in hemodynamics triggered by the distinct physiological stress of pneumoperitoneum. In laparoscopic surgery, pneumoperitoneum serves as a complex stimulus, inducing hypertension through elevated intra-abdominal pressure (altering venous return and afterload), hypercapnia, and neuroendocrine responses (involving catecholamines, the renin-angiotensin system, and vasopressin), making it an ideal model for evaluating how anesthetic agents modulate these responses. This study aims to examine hemodynamic changes in response to pneumoperitoneum according to the anesthetic agent used for maintenance. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Patients who underwent laparoscopic surgery (or intra-abdominal surgery excluding thoracoscopic surgery) under general anesthesia at this facility between August 1, 2020, and March 31, 2026. Key exclusion criteria - Patients with missing data Target Size - 150

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 10 Month 01 Day Anticipated trial start date - 2026 Year 10 Month 31 Day Last follow-up date - 2026 Year 10 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071968

Disclaimer: Curated by HT Syndication.