Tokyo, Oct. 8 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000063209) titled 'Effects of cocoa supplementation and aerobic exercise on arterial stiffness in sedentary middle-to-late aged adults' on Oct. 7.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Single blind -investigator(s) and assessor(s) are blinded Control - No treatment

Primary Sponsor: Institute - Universiti Malaya

Condition: Condition - Arterial stiffness Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To investigate the effects of 8 weeks of cocoa supplementation and aerobic exercise on arterial stiffness in sedentary middle-to-late adults. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Participants in the COEX group consumed 100% cocoa powder daily at a dose of 0.17 g/kg/day for 8 weeks and participated in a supervised square dancing program three times per week for 8 weeks. Each session lasted 60 minutes and consisted of a 10-minute warm-up, 40 minutes of square dancing, and a 10-minute stretching period.

Exercise intensity was maintained at 50% to 70% of age-predicted maximum heart rate (HRmax). HRmax was estimated using the formula 220 minus age. Participants received real-time heart rate feedback and adjusted exercise intensity to remain within the target heart rate range. When heart rate was below the target range, participants increased movement amplitude and stepping cadence. When heart rate exceeded the target range, participants reduced movement amplitude and exercise pace until heart rate returned to the prescribed range. All exercise sessions were supervised by an instructor. Interventions/Control_2 - Participants in the COCO group consumed 100% cocoa powder at a dose of 0.17 g/kg/day for 8 weeks. The cocoa powder was mixed with 120 mL of water and consumed 30 minutes after dinner, without added milk or sugar. Before the intervention, participants completed a 1-week food diary to identify the use of other polyphenol-rich food supplements. Participants were instructed to maintain their dietary habits as closely as possible to those recorded in the food diary throughout the intervention period.

Eligibility: Age-lower limit - 55 years-old = Gender - Male and Female Key inclusion criteria - Aged 55-65 years middle-to-late adults; BMI < 30 kg/m2 (non-obese); middle-to-late adults who exercise less (exercising fewer than 150 minutes per week of moderate activity); Key exclusion criteria - Have cardiovascular disease and any kidney, lung, or metabolic disorders. Target Size - 45

Recruitment Status: Recruitment status - Completed Date of protocol fixation - 2025 Year 04 Month 25 Day Date of IRB - 2025 Year 04 Month 25 Day Anticipated trial start date - 2025 Year 06 Month 15 Day Last follow-up date - 2025 Year 09 Month 30 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072346

Disclaimer: Curated by HT Syndication.