Tokyo, Feb. 28 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060752) titled 'Effects of Nostoc commune hot-water extract intake on salivary IgA in healthy adults' on Feb. 28.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Open -no one is blinded Control - Placebo

Primary Sponsor: Institute - Kitasato University

Condition: Condition - Healthy adults (mucosal immunity assessment) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The objective of this study is to evaluate the effects of hot-water extract of edible cyanobacteria Nostoc commune on salivary secretory immunoglobulin A (sIgA) levels in healthy adults using a randomized crossover design. This study aims to assess mucosal immune responses and explore the potential of Nostoc commune as a functional food material. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Participants ingest 100mL of a beverage made by extracting 1g of Nostoc with 100mL of hot water. After an overnight fast, salivary samples are collected repeatedly up to 120 minutes post-intake. A 6-day washout period is applied before crossover to the control condition. Interventions/Control_2 - Participants ingest 100 mL of water as the control beverage under identical conditions. Saliva is collected repeatedly under the same protocol, followed by crossover after a 6-day washout period.

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Healthy adults aged 18 years or older Students or staff at Kitasato University Sagamihara campus Provided written informed consent Key exclusion criteria - Allergy to Nostoc commune components Fever 37.5 C or higher Regular medication use Immunodeficiency anticoagulant therapy or significant underlying disease Target Size - 20

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 02 Month 20 Day Date of IRB - 2026 Year 02 Month 25 Day Anticipated trial start date - 2026 Year 03 Month 01 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069476

Disclaimer: Curated by HT Syndication.