Tokyo, Oct. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062977) titled 'Effects of Short-Term Upper Limb Immobilization on Motor Imagery and Upper Limb Activity' on Oct. 1.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Uncontrolled

Primary Sponsor: Institute - Nagoya City University

Condition: Condition - Secondary fracture after distal radius fracture Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Distal radius fracture, a common initial fragility fracture, is associated with a high risk of subsequent fractures, including hip fractures. Based on our previous findings, changes in bilateral symmetry of upper-limb activity and dynamic balance function have been identified as potential factors contributing to secondary fracture risk. Previous studies have also reported that short-term immobilization may reduce muscle contraction efficiency and motor imagery ability. However, the causal relationships among these factors remain unclear. This study aims to investigate the effects of short-term upper-limb immobilization on these factors and thereby elucidate part of the mechanism underlying secondary fractures. The findings of this study are expected to contribute to the development of novel intervention strategies. Basic objectives2 - Others

Intervention: Interventions/Control_1 - 24-hour immobilization of the non-dominant upper limb

Eligibility: Age-lower limit - 18 years-old

Gender - Male and Female Key inclusion criteria - Healthy adults aged 18 years or older and younger than 50 years who are determined to be right-handed based on a laterality quotient of 90% or higher on the Edinburgh Handedness Inventory. Participants must have no history of orthopedic or central nervous system disorders that could affect upper limb function, motor imagery, or balance function, and must provide written informed consent to participate in the study. Key exclusion criteria - Participants who have been diagnosed with osteoporosis Participants with a bone mineral density of less than 80% of the young adult mean (YAM) Participants with underlying diseases that may cause bone fragility Target Size - 40

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 10 Month 01 Day Anticipated trial start date - 2026 Year 11 Month 01 Day Last follow-up date - 2029 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072106

Disclaimer: Curated by HT Syndication.