Tokyo, Sept. 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062805) titled 'Efficacy of group intervention for Cognitive Disengagement Syndrome' on Sept. 10.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Uncontrolled

Primary Sponsor: Institute - Ryukoku University

Condition: Condition - cognitive disengagement syndrome Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Cognitive Disengagement Syndrome is a newly conceptualized clinical syndrome characterized by daydreaming, mental confusion, and slowed behavior and speech, with a prevalence of approximately 5%. Although it resembles the predominantly inattentive presentation of ADHD, it is symptomatologically distinct: individuals with CDS tend to disengage easily from external stimuli and become absorbed in their internal world, which delays task processing and makes it difficult to keep pace with conversation--often leading others to misinterpret this as laziness or indifference. CDS also shows high comorbidity with depression and anxiety disorders, and tends to respond poorly to ADHD pharmacotherapy and existing psychosocial interventions. To date, most research has focused on demonstrating symptomatological differences from ADHD, while studies in other domains remain sporadic. Recently, under the view that CDS constitutes an "independent diagnostic entity," it was concluded that "further research is needed to inform intervention" (Becker et al., 2023). Accordingly, this study aims to optimize intervention by conducting a group for individuals with CDS. As a pilot group, this iteration will center on an existing psychosocial treatment program originally developed for ADHD. Given that CDS is closely related to ADHD, some degree of effectiveness is anticipated; however, aspects of insufficient efficacy are also expected to remain. Through post-group interviews and questionnaires, this study will clarify both the effective aspects and limitations of the existing approach, as well as the difficulties CDS presents in adult daily life, in order to inform the design of subsequent group interventions. Basic objectives2 - Safety,Efficacy

Intervention: Interventions/Control_1 - The content of the group generally follows a six-month protocol (held once a month) designed for adults with ADHD. Specifically, it consists of components such as "psychoeducation," "organization skills," "money management," "cognitive behavioral therapy," "time management," and "peer discussion among participants."

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Inclusion criteria were adults aged 18 years or older who had previously been suspected of having CDS, and who were able to converse, read, and write in Japanese. Key exclusion criteria - Exclusion criteria were set as follows: (1) having a psychiatric disorder such as moderate or greater depression, (2) having a diagnosis of epilepsy or intellectual/developmental disorder, and (3) not having obtained the attending physician's permission to participate in the study. Target Size - 10

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 09 Month 10 Day Date of IRB - 2026 Year 08 Month 17 Day Anticipated trial start date - 2026 Year 09 Month 19 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071900

Disclaimer: Curated by HT Syndication.