Tokyo, July 13 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058445) titled 'Efficacy of Interleukin-6 Inhibitors in Neuro-Behcet's Disease: A Systematic Review and Meta-Analysis' on July 12.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Yokohama City University Graduate School of Medicine

Condition: Condition - Neuro-Behcet's disease Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Behcet's disease is a chronic, relapsing, systemic inflammatory disorder characterized by four major clinical manifestations: oral aphthous ulcers, genital ulcers, skin lesions, and ocular involvement. While the efficacy of TNF inhibitors has been well established, their effects on neurological involvement are often insufficient. The effectiveness of interleukin-6 (IL-6) inhibitors for neuro-Behcet's disease remains unclear. This study aims to evaluate the efficacy of IL-6 inhibitors in patients with neuro-Behcet's disease through a systematic review and meta-analysis. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - (1) Case reports, case series, case-control studies, cohort studies, and randomized clinical trials are eligible. (2) Studies involving patients clinically diagnosed with neuro-Behcet's disease are eligible. (3) Studies evaluating the efficacy and safety of IL-6 inhibitors in neuro-Behcet's disease are eligible. Key exclusion criteria - (1) Systematic reviews or meta-analysis papers. (2) Republished research literature will be excluded unless it contains new findings related to the efficacy or safety of IL-6 inhibitors. (3) Research published in languages other than English.

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 07 Month 12 Day Anticipated trial start date - 2025 Year 07 Month 12 Day Last follow-up date - 2026 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066826

Disclaimer: Curated by HT Syndication.