Tokyo, March 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060874) titled 'Efficacy and Safety of Sacubitril/Valsartan in Hypertensive Patients' on March 9.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Uncontrolled

Primary Sponsor: Institute - Kansai Medical University

Condition: Condition - Hypertension Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - We will examine the efficacy and safety of sacubitril/valsartan in comparison with renin-angiotensin-aldosterone system inhibitors in Japanese hypertensive patients. Basic objectives2 - Safety,Efficacy

Intervention: Interventions/Control_1 - All patients were switched from renin-angiotensin system inhibitor (angiotensin-converting enzyme inhibitor or angiotensin receptor II blocker) to sacubitril/valsartan. Patients were initially instructed to take sacubitril/valsartan 100 mg once daily, and dosage was gradually increased up to 200 mg once daily and continued for 24 weeks.

Eligibility: Age-lower limit - 18 years-old < Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1) Hypertension 2) Switched from renin-angiotensin inhibitors to sacubitril/valsartan 3) Home blood pressure levels before switching did not achieve the target levels 4) Recording home blood pressure monitoring Key exclusion criteria - 1) Received sacubitril/valsartan less than six months. 2) Non-sinus rhythm 3) Secondary hypertension 4) Myocardial infarction and/or stroke less than 30 days 5) Receiving regular hemodialysis therapy Target Size - 50

Recruitment Status: Recruitment status - No longer recruiting Date of protocol fixation - 2022 Year 01 Month 04 Day Date of IRB - 2025 Year 10 Month 22 Day Anticipated trial start date - 2022 Year 01 Month 04 Day Last follow-up date - 2026 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000065227

Disclaimer: Curated by HT Syndication.