Clinical Trial: Elucidating the longitudinal changes in cortical function, structure, and networks during perceptual learning (Japan)

Tokyo, Aug. 16 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062246) titled 'Elucidating the longitudinal changes in cortical function, structure, and networks during perceptual learning' on Aug. 16.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Single blind -participants are blinded Control - Placebo

Primary Sponsor: Institute - Niigata University of Health and Welfare

Condition: Condition - Healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To clarify how interventions using perceptual learning (repetitive peripheral electrical stimulation) and transcranial alternating current stimulation (tACS) over the TPJ affect neurotransmitter (e.g., GABA) concentration, white matter microstructure, functional networks, EEG activity, and somatosensory function (two-point discrimination) centered on the TPJ. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Experiment 1: Repetitive peripheral electrical (somatosensory) stimulation at 10-20 Hz to the index fingertip for 20 minutes (active). Interventions/Control_2 - Control: Corresponding sham stimulation for 20 minutes on a separate day.

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Healthy adults aged 18-35 years who can understand the explanation of the experiment and provide voluntary written informed consent. Key exclusion criteria - History of neurological disease (e.g., stroke, epilepsy) or psychiatric disease (e.g., depression, schizophrenia); use of drugs affecting the central nervous system; claustrophobia; metal implants in the body; pregnancy; any item applicable on the MRI screening questionnaire; participants who cannot tolerate the minimum required stimulation intensity due to pain or discomfort. Target Size - 120

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 06 Month 19 Day Anticipated trial start date - 2026 Year 08 Month 16 Day Last follow-up date - 2029 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071226

Disclaimer: Curated by HT Syndication.