Tokyo, June 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061707) titled 'Elucidating the mechanisms of meniscal degeneration and extrusion in knee osteoarthritis using RNA sequencing' on June 1.
Study Type:
Others,meta-analysis etc
Primary Sponsor:
Institute - Osaka Medical and Pharmaceutical University
Condition:
Condition - knee osteoarthritis
Classification by malignancy - Others
Genomic information - YES
Objective:
Narrative objectives1 - In osteoarthritis of the knee, RNA-seq will be performed on meniscal tissue from groups with severe meniscal extrusion and groups with mild/no meniscal extrusion to clarify differences in cell subset composition, gene expression profiles, and signaling networks, thereby elucidating the molecular and cellular mechanisms of meniscal extrusion.
Basic objectives2 - Others
Eligibility:
Age-lower limit - 60
years-old
Gender - Female
Key inclusion criteria - Patients with osteoarthritis of the knee
Age 60 to under 70. Female.
Written informed consent obtained from the research participant.
Key exclusion criteria - Inflammatory joint diseases such as chronic rheumatoid arthritis and crystal-induced arthritis
History of infectious arthritis
Cases in which the same knee has undergone extensive meniscectomy or artificial joint replacement in the past
Cases where participation in the study is deemed inappropriate due to severe systemic complications
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 05 Month 27 Day
Anticipated trial start date - 2026 Year 05 Month 27 Day
Last follow-up date - 2030 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070606
Disclaimer: Curated by HT Syndication.
