Tokyo, Dec. 31 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060156) titled 'Elucidation of Molecular Mechanisms Underlying Exercise-Induced Mood Improvement Using a Human Knockout Model' on Dec. 31.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Open -no one is blinded Control - No treatment

Primary Sponsor: Institute - Yamanashi Gakuin University

Condition: Condition - Healthy adult men Classification by malignancy - Others Genomic information - YES

Objective: Narrative objectives1 - This study biochemically investigates whether endocannabinoids (eCBs) mediate acute exercise-induced mood improvement, utilizing a human knockout model based on gene expression capacity. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Participants will perform cycle ergometer exercise at 40% heart rate reserve for 30 minutes in the exercise condition, and maintain a resting state for 30 minutes in the control condition. Interventions/Control_2 - Magnetic resonance spectroscopy (MRS) will be performed after the intervention. During the MRS acquisition, mood fluctuations will be induced using the Open Affective Standardized Image Set (OASIS).

Eligibility: Age-lower limit - 18 years-old = Gender - Male Key inclusion criteria - Untrained individuals Key exclusion criteria - Individuals with abnormal findings in medical check-ups. Individuals currently taking medication. Current smokers. Individuals unable to perform exercise at the prescribed intensity. Individuals with a history of vasovagal reflex (fainting) during blood sampling. Target Size - 60

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 21 Day Date of IRB - 2025 Year 12 Month 01 Day Anticipated trial start date - 2026 Year 03 Month 01 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068801

Disclaimer: Curated by HT Syndication.