Tokyo, June 9 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061824) titled 'Elucidation of the Effects of Antidiabetic Drugs on the Progression of Diabetic Nephropathy via the Bacteria-Derived Peptide Corisin' on June 8.

Study Type: Observational

Primary Sponsor: Institute - Mie University

Condition: Condition - diabetes mellitus Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - In this study, we will investigate whether administration of the target drugs (metformin, SGLT2 inhibitors, GLP-1 receptor agonists, and GLP-1/GIP receptor agonists) alters the systemic levels of the microbiota-derived peptide corisin and examine its association with parameters related to the progression of vascular complications, including diabetic nephropathy. These parameters will include clinical laboratory data obtained during routine medical care, patient background information extracted from electronic medical records, and results of corisin-related laboratory analyses performed in our research laboratory. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients scheduled to receive treatment with metformin, SGLT2 inhibitors, GLP-1 receptor agonists, or GLP-1/GIP receptor agonists at Mie University Hospital. Patients aged 20 years or older. Patients (or their legally authorized representatives) who provide written informed consent. Key exclusion criteria - Patients whom the principal investigator or a sub-investigator judges to be unsuitable for inclusion in the study. Target Size - 200

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2026 Year 04 Month 27 Day Date of IRB - 2026 Year 05 Month 08 Day Anticipated trial start date - 2026 Year 05 Month 08 Day Last follow-up date - 2032 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070678

Disclaimer: Curated by HT Syndication.