Tokyo, April 8 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061178) titled 'Elucidation of the Molecular Basis of Life-to-Death Transition: A Prospective Observational Study to Identify Biological Responses of Life Maintenance and Revitalization' on April 7.

Study Type: Observational

Primary Sponsor: Institute - Nara medical university hospital

Condition: Condition - Heart disease, Kidney disease, Malignant neoplasm, and Infectious disease Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - To elucidate the molecular basis of the "Life Extension System," which encompasses biological responses involved in the recovery, resuscitation, and maintenance of life. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients currently hospitalized at the Department of Cardiology/Nephrology, Nara Medical University Hospital, Nanwa Hospital, or Nishinokyo Hospital who have a medical history of any of the following conditions. Acute death model: Patients with severe acute heart failure, cardiogenic shock, fatal arrhythmia requiring mechanical circulatory support, or those in the terminal stage due to the progression of irreversible and fatal diseases. Slow death model: High-risk patients undergoing maintenance dialysis, patients requiring emergency initiation of dialysis, patients with chronic kidney disease complicated by severe infection, or patients with end-stage kidney disease who have opted for conservative kidney management. Key exclusion criteria - Patients judged by the investigator to be unsuitable as subjects. Target Size - 200

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 03 Month 31 Day Date of IRB - 2026 Year 03 Month 31 Day Anticipated trial start date - 2026 Year 04 Month 17 Day Last follow-up date - 2031 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069832

Disclaimer: Curated by HT Syndication.