Tokyo, April 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061324) titled 'Evaluation of Biological Age using Salivary HSP70 and its Association with Frailty' on April 20.
Study Type:
Observational
Primary Sponsor:
Institute - Saishunkan Pharmaceutical Co., Ltd.
Condition:
Condition - Healthy Adults
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - To cross-sectionally investigate the association between non-invasively collected salivary HSP70 concentration and frailty (physical, social, and psychological) as well as its components (physical function indicators). Additionally, to verify whether salivary HSP70 can serve as an indicator reflecting "Biological Age" independent of chronological age.
Basic objectives2 - Efficacy
Eligibility:
Age-lower limit - 18
years-old
<=
Age-upper limit - Not applicable
Gender - Male and Female
Key inclusion criteria - 1. Persons who received a sufficient explanation of the purpose and contents of the study, have the capacity to consent, applied with free will with sufficient understanding, and agreed to participate.
2. Japanese persons who are 18 years old or more at the time of consent.
3. Persons who can visit the measurement venue.
Key exclusion criteria - 1. Persons with currently treated malignant tumors, severe heart failure or respiratory disease, chronic kidney disease requiring dialysis, or serious autoimmune diseases.
2. Persons currently receiving systemic steroid administration or immunosuppressant treatment.
3. Persons with obvious paralysis due to sequelae of cerebrovascular disease or those with neurodegenerative diseases.
4. Persons for whom walking or grip strength measurement is physically difficult due to acute fractures or joint diseases.
5. Persons with significant salivary secretion disorders such as Sjogren's syndrome.
6. Persons who have participated in other studies within one month before the start of the study, or those who intend to participate in another study after consenting to this study.
7. Persons judged as inappropriate by the principal investigator.
8. Persons who are pregnant or breastfeeding.
Target Size - 300
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 04 Month 14 Day
Date of IRB - 2026 Year 04 Month 14 Day
Anticipated trial start date - 2026 Year 06 Month 01 Day
Last follow-up date - 2027 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070163
Disclaimer: Curated by HT Syndication.
