Clinical Trial: Evaluation of the effects of tongue cleaning and oil pulling on Gut Microbiota based on the Oral-Gut Axis (Japan)

Tokyo, Dec. 23 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060164) titled 'Evaluation of the effects of tongue cleaning and oil pulling on Gut Microbiota based on the Oral-Gut Axis' on Dec. 22.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -but assessor(s) are blinded Control - Active

Primary Sponsor: Institute - Kyoto University

Condition: Condition - Healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To examine whether tongue cleaning and oil pulling, as forms of self-oral care, can improve the balance of the gut microbiota in healthy adults through the modulation of the oral microbiota. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Tongue cleaning every morning for 3 months Interventions/Control_2 - Oil pulling every morning for 3 months

Eligibility: Age-lower limit - 18 years-old

Gender - Male and Female Key inclusion criteria - 1. Adults aged 18 years or older and younger than 65 years 2. Healthy individuals Key exclusion criteria - 1. Individuals who have practiced tongue cleaning, oil pulling, or mouthwash use within the past month 2. Individuals who have taken, within the past month, medications (e.g., antibiotics, immunosuppressants, chemotherapy), probiotics, supplements, or functional foods that affect the gut microbiota 3. Women who are pregnant or breastfeeding 4. Individuals currently undergoing treatment for periodontitis 5. Individuals with sesame oil allergy 6. Individuals with a history of or currently undergoing treatment for malignant neoplasms of the digestive system 7. Any other individuals deemed inappropriate for participation in this study by the principal investigator Target Size - 40

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 18 Day Anticipated trial start date - 2026 Year 01 Month 26 Day Last follow-up date - 2027 Year 06 Month 30 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067361

Disclaimer: Curated by HT Syndication.