Tokyo, April 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060899) titled 'An Exploratory Study of Senescence Associated Glycoprotein (SAGP) in Idiopathic Pulmonary Fibrosis: A Cross Sectional Study Using Blood and Lung Tissue Samples' on April 1.

Study Type: Observational

Primary Sponsor: Institute - Juntendo University Hospital

Condition: Condition - Idiopathic pulmonary fibrosis Classification by malignancy - Others Genomic information - YES

Objective: Narrative objectives1 - The objective of this study is to investigate the presence and expression of senescence-associated glycoprotein (SAGP) in patients with idiopathic pulmonary fibrosis (IPF) using peripheral blood and lung tissue samples. Specifically, we aim to measure circulating SAGP levels in patients with IPF and explore their associations with clinical parameters, including pulmonary function, radiologic findings, established biomarkers, and DNA methylation profiles. In cases undergoing diagnostic lung biopsy, protein analysis and single-cell analysis will be performed to identify SAGP-positive cells and characterize their cell-type specificity, thereby clarifying the involvement of cellular senescence in the pathogenesis of IPF. Basic objectives2 - Bio-availability

Eligibility: Age-lower limit - 16 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1. Individuals aged 16 years or older at the time of obtaining informed consent.

2. Individuals who are suspected of having or have been diagnosed with idiopathic pulmonary fibrosis.

3. Individuals who have received sufficient explanation about the study and have provided written informed consent of their own free will. Key exclusion criteria - Individuals who are judged by the principal investigator to be inappropriate for participation in this study. Target Size - 40

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 03 Month 10 Day Anticipated trial start date - 2026 Year 04 Month 01 Day Last follow-up date - 2031 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069692

Disclaimer: Curated by HT Syndication.