Tokyo, Aug. 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058874) titled 'A study on knee joint movement in normal knees and osteoarthritis of the knee' on Aug. 23.

Study Type: Observational

Primary Sponsor: Institute - Saitama medical university

Condition: Condition - Knee osteoarthritis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To analyze and compare the knee joint kinematics during weight-bearing movements in normal knees group, mild osteoarthritis of the knee group, and severe osteoarthritis of the knee group using X-ray fluoroscopic kinematic analysis, in order to elucidate the changes in knee joint dynamics associated with the progression of osteoarthritis of the knee and to clarify part of the mechanism underlying the progression of osteoarthritis of the knee. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Normal knee: Individuals aged 18 years or older and 90 years or younger at the time of informed consent Individuals with no deformity of the knee joint on plain X-ray images Individuals who have received adequate explanation regarding participation in this study, demonstrated sufficient understanding, and provided written informed consent of their own free will

Osteoarthritis of the knee: Individuals diagnosed with osteoarthritis of the knee at Kellgren-Lawrence grade 2 or higher on plain X-ray images Individuals for whom motion analysis tests are recommended for assessing the condition Key exclusion criteria - Normal knee: Individuals requiring surgical treatment for ligament or cartilage damage Individuals who have undergone surgical treatment affecting alignment, such as fractures or osteotomy Individuals with systemic diseases affecting the knee joint (e.g., collagen diseases) Pregnant women or women who may be pregnant Breastfeeding women Other patients deemed inappropriate for participation by the principal investigator (or co-investigator)

Osteoarthritis of the knee: Individuals unable to perform activities of daily living independently Pregnant women or women who may be pregnant Breastfeeding women Other patients deemed inappropriate for participation by the principal investigator (or co-investigator) Target Size - 100

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 08 Month 23 Day Anticipated trial start date - 2025 Year 10 Month 07 Day Last follow-up date - 2030 Year 10 Month 06 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067328

Disclaimer: Curated by HT Syndication.