Tokyo, Aug. 25 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062672) titled 'Effects of motor imagery combined with action observation and electrical stimulation on corticospinal excitability and imagery vividness' on Aug. 25.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Open -no one is blinded Control - No treatment

Primary Sponsor: Institute - Nagasaki University

Condition: Condition - healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to investigate the effects of combining action observation (AO) and neuromuscular electrical stimulation (NMES) with motor imagery (MI) of wrist flexion on corticospinal excitability, assessed using motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS), and subjective vividness of MI in healthy adults. By identifying intervention conditions that more effectively facilitate MI-related corticospinal excitability, this study may contribute to the optimization of MI-based interventions for individuals with stroke or musculoskeletal disorders and to the further development of neurorehabilitation. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - neuromuscular electrical stimulation Interventions/Control_2 - action observation + motor imagery

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Healthy adults Key exclusion criteria - Heart disease, Head trauma, History of neurosurgery, History of spinal surgery, Central nervous system disorders, History of convulsions or epilepsy, History of fainting, Family history of epilepsy, Conditions aggravated by stress (e.g., asthma), Post-cardiac pacemaker implantation, Presence of implanted metal in the body, Respiratory or circulatory disorders, Neuropsychiatric disorders, Pregnancy, Hypertension, Hearing abnormalities or tinnitus, Sleep deprivation, Use of medications that lower the seizure threshold Target Size - 30

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 08 Month 06 Day Date of IRB - 2026 Year 08 Month 06 Day Anticipated trial start date - 2026 Year 08 Month 25 Day Last follow-up date - 2027 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071708

Disclaimer: Curated by HT Syndication.