Tokyo, Aug. 8 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058722) titled 'Impact of increased blood flow in the retinal arteriole on vascular function' on Aug. 7.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Single blind -participants are blinded Control - No treatment

Primary Sponsor: Institute - Kitasato University

Condition: Condition - healthy adult males Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To clarify whether increased retinal blood flow enhances vascular function in retinal arterioles Basic objectives2 - Others

Intervention: Interventions/Control_1 - rest hypercapnia (5%CO2 + 21%O2 + N2 balance)-> (washout)-> handgrip exercise (30% of maximal voluntary contraction)-> (washout)-> warming the periocular area (45 degrees Celsius) Interventions/Control_2 - rest-> warming the periocular area (45 degrees Celsius)-> (washout)-> hypercapnia(5%CO2 + 21%O2 + N2 balance)-> (washout)-> handgrip exercise (30% of maximal voluntary contraction))

Eligibility: Age-lower limit - 18 years-old = Gender - Male Key inclusion criteria - Healthy adults without chronic disease Participants who provided informed consent after receiving an explanation of the study protocol Participants whose lifestyle habits, such as physical activity and dietary intake, do not undergo significant changes on the day before or the day of the experiment Key exclusion criteria - Participants who have been advised by a physician to refrain from exercise Participants who have been diagnosed with electrocardiographic abnormalities or heart disease by a physician Participants who have experienced sudden loss of consciousness or episodes of palpitations Participants who currently have or have had Kawasaki disease or rheumatic fever Participants who currently have or have had eye diseases Participants who have been diagnosed with anemia or received treatment for anemia by a physician Participants whose compliance with the study protocol is in doubt Target Size - 29

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 07 Month 04 Day Anticipated trial start date - 2025 Year 09 Month 30 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067128

Disclaimer: Curated by HT Syndication.