Clinical Trial: Informational Perturbation Resolves Precision Collapse and Restores Adaptive Neural Dynamics (Japan)

Tokyo, Jan. 7 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060274) titled 'Informational Perturbation Resolves Precision Collapse and Restores Adaptive Neural Dynamics' on Jan. 6.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Single blind -investigator(s) and assessor(s) are blinded Control - Placebo

Primary Sponsor: Institute - TIC-DO institute

Condition: Condition - Neural functional frozen attractor Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The purpose of this study is to investigate the computational mechanisms of the brain's proprioceptive prediction error processing. Specifically, we aim to verify whether a specific light-touch intervention (Specific Informational Perturbation: SIP) can reset frozen neural dynamics and restore adaptive physiological states. This research comprises three sub-studies: Study 1 (RCT): Investigates the existence of the effect compared to a sham (placebo). Study 2 (Specificity): Investigates whether the effect depends on the type of stimulus. Study 3 (Ecological): Validates the effect in a home environment. Basic objectives2 - Others

Intervention: Interventions/Control_1 - Specific informational perturbation Interventions/Control_2 - Sham

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Health Status: Participants were healthy individuals with no history of psychiatric or neurological disorders and were not currently using psychotropic or neuroactive medications. Inclusion Criteria: Inclusion was restricted to individuals demonstrating latent proprioceptive deficits at baseline, defined as a Free Energy Proxy ($F$) > 0.8. Key exclusion criteria - Psychiatric or neurological disorders and were currently prescribed psychotropic or neuroactive medications Target Size - 106

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 14 Day Date of IRB - 2025 Year 12 Month 14 Day Anticipated trial start date - 2026 Year 01 Month 06 Day Last follow-up date - 2026 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068947

Disclaimer: Curated by HT Syndication.