Tokyo, Nov. 29 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059461) titled 'Isovolumetric Relaxation Time and Pulmonary Vascular Resistance in Idiopathic Pulmonary Fibrosis: A Retrospective Single-Center Study' on Nov. 28.

Study Type: Observational

Primary Sponsor: Institute - Nippon Medical School

Condition: Condition - Idiopathic Pulmonary Fibrosis (IPF) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The aim of this study is to determine whether right ventricular isovolumetric relaxation time (IRT) obtained by echocardiography can serve as a noninvasive indicator of pulmonary vascular resistance (PVR) measured by right heart catheterization in patients with idiopathic pulmonary fibrosis (IPF). Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old 15 mmHg.

Combined pulmonary fibrosis and emphysema (CPFE) as determined by two pulmonologists and one radiologist, defined as upper-lobe predominant emphysema coexisting with lower-lobe predominant fibrosis on HRCT.

Chronic thromboembolic pulmonary hypertension confirmed by CT pulmonary angiography or ventilation-perfusion (V/Q) scanning.

Non-IPF interstitial lung diseases, including connective tissue disease-associated ILD, hypersensitivity pneumonitis, or sarcoidosis.

Atrial fibrillation or other significant arrhythmias interfering with accurate time-interval measurements.

Poor echocardiographic image quality precluding reliable Doppler waveform analysis.

Missing key hemodynamic or echocardiographic data (mPAP, PAWP, cardiac output, IRT, PAAcT, etc.).

Patients who had initiated pulmonary arterial hypertension-specific therapy prior to RHC or echocardiographic evaluation.

Patients with acute exacerbation, respiratory infection, or clinically unstable condition at the time of evaluation. Target Size - 121

Recruitment Status: Recruitment status - No longer recruiting Date of protocol fixation - 2020 Year 10 Month 01 Day Date of IRB - 2025 Year 10 Month 01 Day Anticipated trial start date - 2020 Year 10 Month 01 Day Last follow-up date - 2025 Year 10 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068007

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