Tokyo, July 15 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062230) titled 'LARS, Individual Personality, and Functional Experience after Rectal Cancer Surgery LIFE-1 study' on July 14.

Study Type: Observational

Primary Sponsor: Institute - Kyoto University

Condition: Condition - Primary rectal adenocarcinoma or rectal neuroendocrine neoplasm Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - The purpose of this study is to investigate risk factors associated with LARS and impaired QOL after sphincter-preserving surgery for rectal cancer, with a particular focus on clarifying the association of preoperative personality traits with postoperative LARS and QOL. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - 1. Patients who have been histopathologically diagnosed with primary rectal cancer, including adenocarcinoma or neuroendocrine neoplasm, or patients in whom these diagnoses are strongly suspected. 2. Patients who are scheduled to undergo curative low anterior resection or intersphincteric resection for rectal cancer. Key exclusion criteria - 1. Patients scheduled to undergo treatment for other malignancies between the diagnosis of rectal cancer and admission for surgery. 2. Patients with active multiple primary cancers, including synchronous multiple cancers or metachronous multiple cancers with a disease-free interval of less than 5 years, who are currently receiving or scheduled to receive treatment. 3. Patients with distant metastasis. 4. Patients undergoing emergency surgery. 5. Patients who have already started neoadjuvant treatment for rectal cancer, including chemotherapy, radiotherapy, or total neoadjuvant therapy, before registration. 6. Patients who have undergone stoma creation related to rectal cancer prior to registration. 7. Patients diagnosed with a psychiatric disorder who are receiving treatment, including pharmacotherapy, at the time of registration. 8. Patients deemed inappropriate for participation by the principal investigator or a co-investigator. Target Size - 160

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 07 Month 10 Day Anticipated trial start date - 2026 Year 07 Month 15 Day Last follow-up date - 2028 Year 07 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070877

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