Tokyo, July 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058574) titled 'Mechanical Energy and Ventilator-Induced Lung Injury: Insights from Four-Dimensional Dynamic CT' on July 24.
Study Type:
Observational
Primary Sponsor:
Institute - Jichi Medical University Saitama Medical Center
Condition:
Condition - Patients who required mechanical ventilation.
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - This study aims to investigate the relationship between mechanical energy measured at the bedside and tidal recruitment or strain in patients with acute respiratory failure, using four-dimensional dynamic respiratory CT (4D-CT), to deepen understanding of ventilator-induced lung injury (VILI) and develop safer ventilation strategies.
Basic objectives2 - Others
Eligibility:
Age-lower limit - 18
years-old
<=
Age-upper limit - Not applicable
Gender - Male and Female
Key inclusion criteria - Patients requiring mechanical ventilation in the intensive care unit
Hemodynamically stable under vasopressor support after initiation of mechanical ventilation
Physician judges that four-dimensional dynamic CT (4D-CT) is necessary and can be performed safely
Key exclusion criteria - Presence of pulmonary fistula or pneumothorax
Severe obstructive pulmonary disease
Pregnant women
Hemodynamic instability
Elevated intracranial pressure
Right heart failure
Target Size - 60
Recruitment Status:
Recruitment status - Enrolling by invitation
Date of protocol fixation - 2025 Year 06 Month 19 Day
Date of IRB - 2025 Year 06 Month 19 Day
Anticipated trial start date - 2025 Year 07 Month 24 Day
Last follow-up date - 2027 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066859
Disclaimer: Curated by HT Syndication.
