Tokyo, March 20 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060992) titled 'Morphological, radiological, and histological comparison of alveolar ridge preservation using two types of bone substitute' on March 20.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -but assessor(s) are blinded Control - Active

Primary Sponsor: Institute - Nagasaki University

Condition: Condition - molar tooth loss Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Alveolar ridge preservation (ARP) is performed to prevent alveolar ridge resorption following the extraction of molars. Two types of bone grafting materials are used for ARP, and their efficacy is compared and evaluated morphologically, radiographically, and histologically. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - hydroxyapatite/collagen composite material Interventions/Control_2 - octacalcium/collagen composite material

Eligibility: Age-lower limit - 20 years-old

Gender - Male and Female Key inclusion criteria - Patients aged 20 years or olde but under 90 years at the time of consent acquisition Patients seeking implant treatment in the molar region Patients who require tooth extraction at the relevant site and need ARP to prevent bone resorption The difference in alveolar bone height between buccal and lingual or palatal sides is within 5 mm Patients who have provided written consent to participate in the study Key exclusion criteria - Patients with acute inflammation at the treatment site Smokers (10 or more cigarettes per day) Pregnant patient Patients with a history of allergy to collagen Patients with uncontrolled metabolic disorders (diabetes, osteomalacia, thyroid disease, severe liver or kidney disease) Patients who are taking long term steroid or immunosuppressive drugs for autoimmune diseases, etc Patients taking antiresorptive agents Patients undergoing radiation therapy Other patients who are not adequate to participate this study Target Size - 24

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2026 Year 02 Month 10 Day Date of IRB - 2026 Year 03 Month 16 Day Anticipated trial start date - 2026 Year 03 Month 19 Day Last follow-up date - 2029 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069793

Disclaimer: Curated by HT Syndication.