Tokyo, Sept. 25 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062971) titled 'MRI-Based Evaluation of the Descending Pain Modulation System Using Proton Magnetic Resonance Spectroscopy and Resting-State Functional MRI in Healthy Adults' on Sept. 25.

Study Type: Observational

Primary Sponsor: Institute - National Institutes for Quantum Science and Technology

Condition: Condition - Healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This observational study aims to establish an MRI-based evaluation method for the descending pain modulation (DPM) system by combining magnetic resonance spectroscopy (MRS) and resting-state functional MRI (fMRI) in healthy adult volunteers. Brain metabolite concentrations and functional connectivity within DPM-related brain regions will be evaluated, and same-day test-retest MRI measurements will be performed to assess the reproducibility and stability of these imaging biomarkers. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old = Gender - Male Key inclusion criteria - 1.Healthy male adults aged 18 to 35 years 2.Right-handed individuals 3.Individuals capable of providing written informed consent 4.Individuals deemed eligible for participation by the investigators Key exclusion criteria - 1.A history of serious neurological, psychiatric, cardiovascular, respiratory, or other disorders, or any such disorder currently requiring treatment 2.A history of organic brain disease 3.Substance dependence 4.Use of medications, supplements, or health foods that may affect brain function or metabolism 5.Contraindications to MRI, including metallic implants, pacemakers, or tattoos 6.Severe claustrophobia 7.Individuals deemed unsuitable for participation by the principal investigator Target Size - 8

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 10 Month 01 Day Date of IRB - 2026 Year 08 Month 28 Day Anticipated trial start date - 2026 Year 10 Month 04 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071932

Disclaimer: Curated by HT Syndication.