Tokyo, Feb. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060529) titled 'Efficacy Tests for Toothpaste and Mouthwash' on Feb. 1.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Single blind -investigator(s) and assessor(s) are blinded Control - Active

Primary Sponsor: Institute - Aichi Gakuin University

Condition: Condition - Periodontal disease Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Evaluate the efficacy of formulations containing CPC and beta-glycyrrhetinic acid in improving periodontal disease compared to formulations containing CHX. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Use of CPC + beta-glycyrrhetinic acid paste and liquid formulations at least twice daily for 3 months. Interventions/Control_2 - Use of chlorhexidine-containing paste and CHX + MAG liquid formulation at least twice daily for 3 months.

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - (1) Patients who have received explanations about the purpose, content, and side effects of this study, fully understood them, voluntarily wished to participate in the study, and provided written informed consent (2) Patients who have 16 or more remaining teeth (3) Patients who have stable teeth with a PPD of 4-8mm, excluding third molars (4) Patients who are 20 years of age or older at the time of obtaining consent Key exclusion criteria - (1) Patients who have been administered antibiotics (antimicrobial agents) within 1 month before the start of the study (2) Patients currently being treated for cancer, stroke, acute myocardial infarction, diabetes, or autoimmune diseases (3) Pregnant or breastfeeding individuals (4) Smokers (5) Patients who have experienced allergic reactions to toothpaste in the past (6) Patients who are visiting a dental clinic and receiving treatment for oral diseases other than periodontal disease (7) Patients currently participating in other clinical trials related to oral health Target Size - 80

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 08 Month 05 Day Date of IRB - 2025 Year 09 Month 29 Day Anticipated trial start date - 2026 Year 02 Month 06 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069219

Disclaimer: Curated by HT Syndication.