Clinical Trial: Observation of the effects of non-surgical periodontal treatment on vascular function and biomarkers in blood and saliva (Japan)

Tokyo, Oct. 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059266) titled 'Observation of the effects of non-surgical periodontal treatment on vascular function and biomarkers in blood and saliva' on Oct. 10.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -no one is blinded Control - Active

Primary Sponsor: Institute - The Nippon Dental University

Condition: Condition - Periodontitis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To investigate whether full-mouth debridement using Er:YAG laser reduce periodontal parameters and systemic effects compared to treatment using ultrasonic scaler. Basic objectives2 - Safety,Efficacy

Intervention: Interventions/Control_1 - Interventions / Subgingival debridement of the full mouth completed in one session using an Er:YAG laser. Interventions/Control_2 - Control / Subgingival debridement of the full mouth completed in one session using an ultrasonic scaler.

Eligibility: Age-lower limit - 20 years-old = Gender - Male and Female Key inclusion criteria - (a) Generalized stage II to IV periodontitis, (b) 12 or more remaining teeth. Key exclusion criteria - (a) Less than 12 remaining teeth (excluding third molars and remaining roots), (b) Periodontal treatment received in the past year, (c) Systemic diseases that may affect periodontitis or periodontal treatment, (d) Pregnant or breastfeeding women, (e) Systemic administration of antibiotics or anti-inflammatory analgesics within three months prior to periodontal examination. Target Size - 28

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2023 Year 03 Month 23 Day Date of IRB - 2023 Year 05 Month 23 Day Anticipated trial start date - 2023 Year 11 Month 24 Day Last follow-up date - 2026 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066405

Disclaimer: Curated by HT Syndication.