Tokyo, Feb. 13 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060658) titled 'A Study on the Determination of Optimal Cutoff Values for Plasma Free Metanephrine and Normetanephrine in the Diagnosis of Pheochromocytoma Based on Real-World Clinical Practice' on Feb. 13.

Study Type: Observational

Primary Sponsor: Institute - University of Tsukuba

Condition: Condition - pheochromocytoma and paraganglioma Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - This study aimed to establish real-world cutoff values for plasma-free fractionated metanephrines for the diagnosis of pheochromocytoma and paraganglioma using measurements obtained in routine clinical settings. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Eligible participants were adults aged 18 years or older who underwent measurement of pMN/pNMN using the 2-MET Plasma ELISA kit (SML) after its reimbursement from January 2019. Key exclusion criteria - The following cases were excluded from the analysis based on medical record review: (1) use of medications known to interfere with metanephrine measurements (e.g., antidepressants, atypical antipsychotics, sympathomimetic agents); (2) ingestion of foods known to affect metanephrine measurements (e.g., caffeine-containing products, bananas, or vanilla) on the day of blood sampling; (3) specimen collection performed during the treatment of acute illnesses or other clinical conditions likely to cause marked sympathetic activation; (4) cases in which the presence or absence of PPGL could not be definitively determined due to insufficient pathological, imaging, or clinical follow-up data. Target Size - 800

Recruitment Status: Recruitment status - No longer recruiting Date of protocol fixation - 2023 Year 03 Month 27 Day Date of IRB - 2023 Year 04 Month 19 Day Anticipated trial start date - 2023 Year 04 Month 19 Day Last follow-up date - 2025 Year 05 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069382

Disclaimer: Curated by HT Syndication.